Systems and methods for performing extracorporeal photopheresis
AssigneeFenwal, Inc.
InventorsLan T. Nguyen, Katherine N. Radwanski, Greg Coultas
Life of this patent
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Abstract
Systems and methods are disclosed for performing online extracorporeal photopheresis in which the needs of a particular patient as to the fluid balance to be achieved and the time allotted to perform the procedure can be prioritized. Whole blood is removed from a patient and introduced through a processing set into a separation chamber to separate the desired cell population from the blood. The separated cell population is processed through the set which is associated with a treatment chamber where the cells are treated. Once treated, the cells are returned to the patient.
Claims17
A method for photoactivating a suspension of target cells separated from a volume of whole blood comprising:
- a) establishing patient and procedure parameters, including a target % of plasma in the suspension of target cells, a fluid balance limit, and a target photoactivation time;
- b) estimating a fluid balance level based on patient and procedure parameters;
- c) comparing the estimated fluid balance level to the fluid balance limit;
- d) If the fluid balance limit is exceeded, i) increasing the target % of plasma in suspension of target cells and recalculating the estimated fluid balance until the recalculated fluid balance is within limit and extending the target photoactivation time proportional to target % plasma in suspension of target cells and/or ii) decreasing the volume of whole blood to be processed and recalculating the estimated fluid balance until the recalculated fluid balance is within fluid balance limit;
- e) collecting a suspension of target cells that achieves a fluid balance within the fluid balance limit;
- and
- f) subjecting the suspension of target cells to phototreatment for the target photoactivation time.
A method for photoactivating a suspension of target cells separated from a volume of whole blood comprising:
- a) establishing patient and procedure parameters, including a target % of plasma in the suspension of target cells and a patient-specific procedure time limit;
- b) estimating a procedure time including an estimated photoactivation time based on patient and procedure parameters;
- c) comparing the estimated procedure time to the patient-specific procedure time limit;
- d) if the patient-specific procedure time limit is exceeded, i) decreasing the target % of plasma in the suspension of target cells and recalculating the estimated procedure time until the recalculated target procedure time is within the patient-specific procedure time limit and/or ii) decreasing the volume of whole blood to be processed and recalculating the estimated procedure time until the recalculated estimated procedure time is within the patient-specific procedure time limit;
- e) collecting a suspension of target cells that achieves an estimated procedure time within the patient-specific procedure time limit;
- and
- f) subjecting the suspension of target cells to phototreatment for the estimated photoactivation time.
A method for photoactivating a suspension of target cells separated from a volume of whole blood comprising:
- a) establishing patient and procedure parameters, including an estimated photoactivation time for the suspension of target cells to be treated based on a default value for plasma clarity and a target % of plasma in suspension of target cells;
- b) separating whole blood into a first component comprising plasma and a second component;
- c) measuring a clarity for the plasma comprising the first component;
- d) comparing the measured plasma clarity to the default value for plasma clarity;
- e) if the measured plasma clarity differs from the default value for plasma clarity, estimating a new photoactivation time based on the measured value for plasma clarity and/or adjusting the target % of plasma in suspension of target cells to be treated to achieve the estimated photoactivation time;
- f) collecting the suspension of target cells;
- and
- g) subjecting the suspension of target cells to phototreatment for the estimated photoactivation time.
A method for photoactivating a suspension of target cells separated from a volume of whole blood comprising:
- a) establishing patient and procedure parameters, including a target % of plasma in the suspension of target cells and a patient-specific procedure time limit;
- b) estimating a procedure time including a target photoactivation time based on patient and procedure parameters;
- c) comparing the estimated procedure time to the patient-specific procedure time limit;
- d) if the patient-specific procedure time limit is exceeded, i) decreasing a hematocrit of the suspension of target cells and/or decreasing the % of plasma in the suspension of target cells, and recalculating the estimated procedure time until the recalculated estimated procedure time is within patient-specific procedure time limit;
- e) collecting the suspension of target cells;
- and
- f) subjecting the suspension of target cells to phototreatment for the estimated target photoactivation time.
An online extracorporeal photopheresis system for photoactivating a suspension of target cells separated from a volume of whole blood comprising:
- (a) a disposable fluid circuit comprising:
- i. a processing chamber for separating whole blood into one or more components including mononuclear cells,
- ii. at least one storage container adapted to receive mononuclear cells wherein at least a portion of said container is transparent to light of a selected wavelength,
- (b) a separation device adapted to receive said processing chamber for effecting separation of said mononuclear cells from whole blood,
- (c) an irradiation device housed separately from said separation device adapted to receive said mononuclear cell storage container for treating said mononuclear cells with a selected dose of light, and
- (d) a programmable controller programmed to automatically perform the steps of a method for photoactivating a suspension of target cells separated from a volume of whole blood.
Dependencies are inferred from the claim text.