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US 2022/0347257 A1Published application
Quorum-sensing inhibitors and/or postbiotic metabolites and related methods
AssigneeMicroSintesis Inc.
InventorMonica Angela Cella
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Abstract
Described herein is a synergistic combination comprising a quorum-sensing inhibitor and/or postbiotic metabolite and an antibiotic. Typically, the postbiotic metabolite comprises at least one peptide. Related compositions, uses, and methods are also described, including methods for resensitizing resistant bacteria to an antibiotic, and methods of treating antibiotic-resistant infections, such as methicillin-resistant Staphylococcus aureus (MRSA).
Claims42
A synergistic combination comprising a quorum-sensing inhibitor and/or a postbiotic metabolite and an antibiotic.
A method for:
- (a) resensitizing an antibiotic-resistant infection to an antibiotic, the method comprising administering a quorum-sensing inhibitor and/or a postbiotic metabolite to a subject afflicted with the infection;
- (b) decreasing resistance of a bacterial infection to hydrogen peroxide cytotoxicity, the method comprising administering a quorum-sensing inhibitor and/or a postbiotic metabolite to a subject afflicted with the infection;
- (c) treating and/or preventing diarrhea in a subject, the method comprising administering a quorum-sensing inhibitor and/or a postbiotic metabolite and an antibiotic to the subject;
- (d) treating MRSA or MRSP, the method comprising administering a quorum-sensing inhibitor and/or a postbiotic metabolite and an antibiotic to a subject afflicted with MRSA or MRSP;
- (e) reducing carotenoid synthesis in bacteria, the method comprising administering a quorum-sensing inhibitor and/or a postbiotic metabolite to the bacteria;
- and/or
- (Ff) sensitizing bacteria to oxidant killing, the method comprising administering a quorum-sensing inhibitor and/or a postbiotic metabolite to the bacteria.
4 more elements
Dependencies are inferred from the claim text.