Nanoparticle complex for treating diseases and method for manufacturing the same
AssigneeSogang University Research Foundation
InventorsHyun Cheol KIM, Do Yeon KIM, Jee Won KIM
Life of this patent
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Abstract
Proposed is a nanoparticle complex containing a nanoparticle that ingestible into a cell, and a lipid-based lipid structure bonded to one portion of an outer surface of the nanoparticle and improving a cellular uptake efficiency of the nanoparticle, wherein the nanoparticle contains a first reactive group, the lipid structure contains a second reactive group chemically bonded to the first reactive group of the nanoparticle, the first reactive group and the second reactive group are chemically bonded to each other, and thus the lipid structure is bonded to the nanoparticle.
Claims12
A nanoparticle complex comprising:
- a nanoparticle that is ingestible into a cell;
- and
- a lipid-based lipid structure bonded to one portion of an outer surface of the nanoparticle and improving a cellular uptake efficiency of the nanoparticle,
- wherein the nanoparticle comprises a first reactive group,
- the lipid structure comprises a second reactive group chemically bonded to the first reactive group of the nanoparticle,
- the first reactive group and the second reactive group are chemically bonded to each other, and
- the lipid structure is thus bonded to the nanoparticle.
A method of manufacturing a nanoparticle, the method comprising:
- forming a nanoparticle having a first reactive group;
- forming a micro-based lipid-based lipidome containing a second reactive group chemically bonded to the first reactive group;
- forming a lipidome-nanoparticle complex by mixing the nanoparticle and the lipidome, bonding the first reactive group and the second reactive group to each other, and thus bonding the nanoparticle to an outer surface of the lipidome;
- and
- breaking the lipidome by applying a mechanical force to the lipidome-nanoparticle complex formed and thus forming a lipid structure bonded to one portion of an outer surface of the nanoparticle,
- wherein in the forming of the lipidome, the lipidome is formed using a mixture of a lipid to which the second reactive group is bonded and a lipid to which the second reactive group is not bonded, the nanoparticle is ingested into a cell, and the lipid structure improves the efficiency of cellular uptake of the nanoparticle.
Dependencies are inferred from the claim text.