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AssigneeEdigene Inc.
InventorsPengfei YUAN, Riguo FANG, Ming JIN, Yongjian ZHANG
Estimating the term…
Disclosed is a method for determining the suitability of a cell therapy for an individual. By means of using a bioinformatic method and an experimental analysis method for an unbiased potential off-target site, a potential off-target site of a genetically modified cell from an individual is predicted before administering a cell therapy to an individual, and the potential off-target site is monitored after administering, to the individual, the genetically modified cell from the individual to determine whether gene editing occurs at the potential off-target site and to evaluate the suitability of the therapy on the basis of the occurrence of a gene editing event.
A method for determining suitability of a cell therapy for an individual, wherein the cell therapy comprises administering a genetically modified cell population from an individual to the individual, wherein the genetically modified cells are modified at a target site through gene editing;
A method for assessing off-target gene editing in a genetically modified cell population or offspring thereof, wherein the genetically modified cells are modified at the target sites through gene editing;
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A method for obtaining multiple off-target tagged sites in a genetically modified cell population, wherein the genetically modified cells are modified at the target sites through gene editing;
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A kit for assessing off-target editing of a genetically modified cell population or offspring thereof, wherein the genetically modified cells are modified at the target sites through gene editing;
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Dependencies are inferred from the claim text.