Methods and kits for preparing radionuclide complexes
AssigneeTheragnostics Limited
InventorsPhilip BLOWER, Gregory MULLEN
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Abstract
A method for preparing a complex comprising a radioisotope of gallium for use in radiotherapy or in a medical imaging procedure, said method comprising adding a gallium radioisotope solution obtained directly from a gallium radionuclide generator to a composition comprising a pharmaceutically acceptable buffer and optionally also a pharmaceutically acceptable basic reagent, in amounts sufficient to increase the pH to a level in the range of 3 to 8, wherein the composition further comprises a chelator that is able to chelate radioactive gallium within said pH range and at moderate temperature, said chelator being optionally linked to a biological targeting agent. Kits and compositions for use in the method are also described and claimed.
Claims11
A method for preparing a complex comprising a radioisotope of gallium for use in a medical imaging procedure, said method comprising adding a gallium radioisotope solution obtained directly from a gallium-68 radionuclide generator, without additional preparation, purification or concentration steps, to a composition comprising a pharmaceutically acceptable buffer, in amounts sufficient to increase the pH to a level in the range of 3 to 8, wherein the composition further comprises a chelator that is able to chelate radioactive gallium within said pH range and at a temperature of 10 to 30° C., said chelator being linked to a biological targeting agent wherein:
- a. said chelator linked to a biological targeting agent is DKFZ-PSMA-11,
- b. the composition further comprises ascorbic acid or gentisic acid,
- c. the composition is in lyophilized or freeze-dried form, and the gallium radioisotope solution is added directly to the lyophilized or freeze-dried composition,
- d. said buffer is a phosphate or acetate buffer, and
- e. wherein the gallium radioisotope solution is a 0.1M HCl eluate.
Dependencies are inferred from the claim text.