Co-crystals of nurr1-lbd in complex with a cyclopentenone prostaglandin and modulators of nurr1
AssigneeNanyang Technological University
InventorsHo Sup YOON, Sreekanth Rajan, Hui Ting Toh, Xuewei Liu, Hui Yao
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Abstract
Co-crystals comprising the Nuclear receptor related 1 protein-ligand binding domain (Nurr1-LBD) and a cyclopentenone prostaglandin are provided. Also provided are methods of identifying or designing Nurr1-modulating ligands and compounds based on the crystal structures described herein as well as the applications of said ligands and compounds as Nurr1 modulators or medicaments.
Claims7
-8. (canceled)
A method of modulating a Nurr1, the method comprising contacting the Nurr1 with an effective amount of a cyclopentenone prostaglandin or a derivative thereof, wherein the cyclopentenone prostaglandin is PGA1 or PGA2, and the derivative of cyclopentenone prostaglandin is not limited to YH279
(canceled)
A method of preventing or treating a disease, disorder, or condition associated with a Nurr1 in a subject, the method comprising administering to said subject an effective amount of a cyclopentenone prostaglandin or a derivative thereof, wherein the cyclopentenone prostaglandin is PGA1 or PGA2, and the derivative of cyclopentenone prostaglandin is not limited to YH279
14-17. (canceled)
Dependencies are inferred from the claim text.