Intestinal microflora and its combination as biomarkers and detection methods for liver cancer
AssigneeNational Yang Ming Chiao Tung University
InventorsChun-Ying WU, Jiunn-Chang LIN
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Abstract
The invention uses intestinal microbial flora and combinations thereof as a liver cancer biomarker and provide a method for detection, in short, the intestinal microbial flora of the invention can be used as a liver cancer biomarker and can be used as a non-invasive method for detecting or predicting liver cancer, combined with conventional blood tests, not only capable of improving the accuracy rate of detection, but also capable of increasing the willingness of patients to participate in detection to achieve the efficacies of early prevention and early treatment.
Claims9
1-4. (canceled)
A biomarker for auxiliary diagnosis and detection of liver cancer, comprising at least one microorganism, wherein the microorganism comes from the following groups of bacterial genera:
- Lachnospira, Succinivibrio, Phascolarctobacterium, rc4_4, Sutterella, WAL 1855D, Methanobrevibacter, Bacteroides, Megasphaera, Dialister, Streptococcus, Acidaminococcus, Epulopiscium, Lactobacillus, Enterococcus, Eubacterium, Rothia, Bifidobacterium, Collinsella, Clostridium, Leuconostoc, Ruminococcus, Rhodococcus, Catenibacterium, Mitsuokella, Roseburia, Granulicatella, Citrobacter, Lactococcus, Coprobacillus, Blautia, Klebsiella, Helicobacter, Succiniclasticum, Peptococcus, Megamonas, Peptostreptococcus, Veillonella, Salmonella, Akkermansia, Corynebacterium and Faecalibacterium.
A biomarker for auxiliary diagnosis and detection of liver cancer, comprising at least one microorganism, wherein the microorganism comes from the following groups of bacterial species:
- Akkermansia muciniphila, Faecalibacterium prausnitzii, Bacteroides barnesiae, Eubacterium biforme, Haemophilus parainfluenzae, Veillonella dispar, Roseburia faecis, Bifidobacterium longum, Collinsella aerofaciens, Lactobacillus mucosae, Helicobacter pylori, Ruminococcus gnavus, Eubacterium dolichum, Rothia mucilaginosa, Mitsuokella multacida, Collinsella stercoris, Lactobacillus zeae, Coprobacillus cateniformis and Rothia aeria.
Dependencies are inferred from the claim text.