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US 2022/0324813 A1Published application
Compositions and methods for the treatment of anal and rectal disorders
AssigneeCellix Bio Private Limited
InventorMahesh Kandula
Life of this patent
Estimating the term…
Abstract
The present invention relates to compounds or its pharmaceutical acceptable polymorphs, solvates, enantiomers, stereoisomers, prodrugs, hydrates and or derivatives thereof. The Pharmaceutical composition comprises an effective amount of compounds of formula I, formula II, formula III, formula IV, Formula V, formula VI or formula VII and the methods of using the composition for treating disorder affecting the anus and rectum. The composition can be formulated for oral administration, rectal administration, topical administration, transmucosal, transdermal administration, spray, injection or other known formulation in the art.
Claims20
-5. (canceled)
A compound of formula VI
- and pharmaceutically acceptable salts, hydrates, solvates, prodrugs, enantiomers, stereoisomers and derivatives thereof,
- wherein, RH independently represents
- NULL, Cl—, Na+, pyridoxine, R-lipoic acid, methyl cellulose, glutamic acid, aspartic acid, valproic acid, prostaglandin F2a, dopamine, morphine, loperamide, b-blockers, sodium valproate, codeine phosphate, N-acetyl cysteine, cysteine, 5-Hydroxytryptamine, Zn+2, Mg+2, Mn+2, I—, Ag+2, Na, K, mesalamine, 1-hydroxy-2-naphthoic acid, 2,2-dichloroacetic acid, 2-hydroxyethanesulfonic acid, 2-oxoglutaric acid, 4-acetamidobenzoic acid, 4-aminosalicylic acid, acetic acid, adipic acid, ascorbic acid, benzenesulfonic acid, benzoic acid, camphoric acid, camphor-10-sulfonic acid, capric acid (decanoic acid), caproic acid (hexanoic acid), carbonic acid, cinnamic acid, citric acid, cyclamic acid, dodecylsulfuric acid, ethane-1,2-disulfonic acid, ethanesulfonic acid, formic acid, galactaric acid, gentisic acid, glucoheptonic acid, gluconic acid, glucuronic acid, glutaric acid, glycerophosphoric acid, glycolic acid, hippuric acid, hydrobromic acid, isobutyric acid, lactic acid, lactobionic acid, lauric acid, maleic acid, malic acid, malonic acid, mandelic acid, methanesulfonic acid, naphthalene-1,5-disulfonic acid, naphthalene-2-sulfonic acid, nicotinic acid, nitric acid, oleic acid, oxalic acid, palmitic acid, pamoic acid, phosphoric acid, proprionic acid, pyroglutamic acid, salicylic acid, sebacic acid, stearic acid, succinic acid, sulfuric acid, tartaric acid, thiocyanic acid, toluenesulfonic acid, undecylenic acid, omega 3 fatty acids, omega 6 fatty acids, furoate, methyl furoate, ethyl furoate, aminocaproic acid, caprilic acid, alpha lipoic acid, myristic acid, myristoleic acid, palmitoleic acid, elaidic acid, linoleic acid, linolenic acid, linolelaidic acid, arachidonic acid,
- and wherein, within the proviso
- each R6, R7 and R8 independently represents
- and wherein, within the proviso, n=0 to 80;
- R1 represents null,
- R2 represents
5 more elements
A compound of formula VII
- and pharmaceutically acceptable salts, hydrates, solvates, prodrugs, enantiomers, stereoisomers and derivatives thereof,
- wherein,
- RH independently represents
- NULL, pyridoxine, R-lipoic acid, methyl cellulose, aspartic acid, valproic acid, prostaglandin F2a, dopamine, morphine, loperamide, b-blockers, sodium valproate, codeine phosphate, N-acetyl cysteine, cysteine, 5-Hydroxytryptamine, Zn+2, Mg+2, Mn+2, I—, Ag+2, Na, K, mesalamine, 1-hydroxy-2-naphthoic acid, 2,2-dichloroacetic acid, 2-hydroxyethanesulfonic acid, 2-oxoglutaric acid, 4-acetamidobenzoic acid, 4-aminosalicylic acid, adipic acid, ascorbic acid, camphoric acid, camphor-10-sulfonic acid, capric acid, caproic acid, cinnamic acid, cyclamic acid, dodecylsulfuric acid, formic acid, galactaric acid, gentisic acid, glucoheptonic acid, gluconic acid, glucuronic acid, glutaric acid, glycerophosphoric acid, glycolic acid, hippuric acid, hydrobromic acid, isobutyric acid, lauric acid, malonic acid, methanesulfonic acid, naphthalene-1,5-disulfonic acid, naphthalene-2-sulfonic acid, nicotinic acid, oleic acid, oxalic acid, palmitic acid, proprionic acid, pyroglutamic acid, sebacic acid, thiocyanic acid, toluenesulfonic acid, undecylenic acid, omega 3 fatty acids, omega 6 fatty acids, furoate, methyl furoate, ethyl furoate, aminocaproic acid, caprilic acid, alpha lipoic acid, myristic acid, myristoleic acid, palmitoleic acid, elaidic acid, linoleic acid, linolenic acid, linolelaidic acid, arachidonic acid,
- and wherein, within the proviso
- each R6, R7 and R8 independently represents
- and wherein, within the proviso, n=0 to 80.
4 more elements
-12. (canceled)
-19. (canceled)
-26. (canceled)
(canceled)
A compound selected from the group of structures consisting of
Dependencies are inferred from the claim text.