Biologically applicable water-soluble heterogeneous catalysts for para-hydrogen induced polarization
AssigneesThe Regents of the University of California, Cedars-Sinai Medical Center
InventorsLouis BOUCHARD, Shawn WAGNER, Stefan GLOEGGLER
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Abstract
A heterogeneous catalyst composition for para-hydrogen induced polarization includes ligand-capped nanoparticles dispersed in water. The ligand-capped nanoparticles include metal nanoparticles that are surface functionalized with organic ligands, a molecular weight of the organic ligands is no greater than 300 g/mol, and the organic ligands each includes multiple binding moieties as coordinates sites for binding to a nanoparticle surface.
Claims21
1-20. (canceled)
A method for inducing hyperpolarization from para-hydrogen, comprising:
- hydrogenating a substrate, in the presence of ligand-capped nanoparticles and a solvent, by flowing or pressurizing para-hydrogen gas to yield a polarized substrate;
- and
- removing the ligand-capped nanoparticles from the polarized substrate,
- wherein the ligand-capped nanoparticles comprise metal nanoparticles that are surface-functionalized with organic ligands, a molecular weight of the organic ligands is no greater than 300 g/mol, and the organic ligands each includes multiple binding moieties as coordinating sites for binding to a nanoparticle surface.
A method for medical imaging, comprising:
- performing the method for inducing hyperpolarization from para-hydrogen of claim 1;
- conveying the polarized substrate to a patient;
- and
- performing in vivo imaging of the polarized substrate conveyed to the patient.
Dependencies are inferred from the claim text.