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AssigneeCenter for Aquaculture Technologies, Inc.
InventorsXavier Christophe Lauth, John Terrell Buchanan
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The disclosure provides a method of generating a sterile fish, crustacean, or mollusk. The method comprises breeding (i) a fertile hemizygous mutated female fish, crustacean, or mollusk with (ii) a fertile hemizygous mutated male fish, crustacean, or mollusk, selecting a female progenitor that is homozygous by genotypic selection, and breeding the homozygous female progenitor to produce the sterile fish, crustacean, or mollusk. The mutation disrupts the maternal-effect of a primordial germ cell (PGC) development gene and does not impair the viability, sex determination, fertility, or a combination thereof, of a homozygous progenitor. The disclosure also provides methods of making broodstock freshwater and seawater organisms for use in producing sterilized freshwater and seawater organisms, as well as the broodstock itself.
A method of generating a sterile fish, crustacean, or mollusk, comprising the steps of:
A fertile homozygous mutated female fish, crustacean, or mollusk for producing a sterile fish, crustacean, or mollusk, wherein the mutation disrupts the post-transcriptional regulation of a primordial germ cell (PGC) development gene to reduce the maternal-effect of the PGC development gene, and wherein the mutation that disrupts the post-transcriptional regulation of a PGC development gene does not impair somatic function of the gene.
A method of breeding a fertile homozygous mutated female fish, crustacean, or mollusk to generate a sterile fish, crustacean, or mollusk, comprising the steps of:
A method of making a fertile homozygous mutated female fish, crustacean, or mollusk that generates a sterile fish, crustacean, or mollusk, comprising the steps of:
Dependencies are inferred from the claim text.