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US 2022/0315529 A1Published application
Nitrilotriacetic acid-containing lipidoid nanoparticles
AssigneeTrustees of Tufts College
InventorsQiaobing Xu, Yamin Li
Life of this patent
Estimating the term…
Abstract
Disclosed are noncationic lipidoid nanoparticles (LNPs) for His-tagged protein delivery.
Claims32
A compound of formula (I):
- or a pharmaceutically acceptable salt thereof, wherein
- Y is a divalent linker;
- W is —NR20—, —O—, or —S—;
- RLipid is independently substituted or unsubstituted C1-20 alkyl, substituted or unsubstituted C1-20 alkenyl, substituted or unsubstituted C1-20 alknyl, substituted or unsubstituted C1-20 heteroalkyl, substituted or unsubstituted C1-20 heteroalkenyl, or substituted or unsubstituted C1-20 heteroalknyl;
- and
- R20 is RLipid, H, C1-6 alkyl, C1-6 alkenyl, or C1-6 alkynyl.
3 more elements
4-5. (canceled)
12-13. (canceled)
15-17. (canceled)
19-22. (canceled)
24-33. (canceled)
(canceled)
A compound selected from the group consisting of:
39-41. (canceled)
43-44. (canceled)
(canceled)
48-49. (canceled)
(canceled)
Dependencies are inferred from the claim text.