Inhibitors of phospholipid synthesis and methods of use

A GPAT inhibitor of the formula (I):

• wherein:
• R′ and R′″ are each independently selected from alkyl, substituted alkyl, alkyl alkenyl, alkyl alkynyl, cycloalkyl, cycloalkyl(alkyl), heterocycloalkyl, heterocycloalkyl(alkyl), substituted heterocycloalkyl, aryl, substituted aryl, aryl(alkyl), substituted aryl(alkyl), heteroaryl, substituted heteroaryl, and halo(alkyl);
• Z′ and Z′″ are optional substituents selected from alkynyl, hydroxy, alkyl(hydroxy), ester, ether, nitrile/cyano, trifluoromethyl, trifluoromethyl ether, trifluoromethyl thioether, trifluoromethyl sulfoxide, trifluoromethyl sulfone, halide, polyalcohol, a straight chain or cyclic saccharide, amine, polyamine, ammonium, amide, azido, nitro, isonitrile, sulfate/sulfonic acid, sulfonate, sulfinate, sulfoxide, sulfone, carboxylate, carboxyl ester, ketone, aldehyde, carboxyl amide, lactone, amidine, sulfonamide, phosphate, phosphonate, phosphinate, boronic acid, boronate ester, amide, thiolate/thiol, thioester, and a carboxy isostere, wherein Z′ or Z′″ optionally forms a bond to a second compound of formula (I);
• R″ is selected from hydrogen, alkyl, substituted alkyl, OR1a, NR1a2 and SR1a;
• R1a is selected H, COR2a, SO2R2a, NHR2a, and NHCOR2a, wherein each R2a are independently selected from alkyl, substituted alkyl, alkyl alkenyl, alkyl alkynyl, cycloalkyl, cycloalkyl(alkyl), heterocycloalkyl, heterocycloalkyl(alkyl), substituted heterocycloalkyl, aryl, substituted aryl, aryl(alkyl), substituted aryl(alkyl), heteroaryl, substituted heteroaryl, and halo(alkyl);
• or R″ and Z′ or Z′″ together with the atoms to which they are attached form a cyclic group selected from heterocycloalkyl, or substituted heterocycloalkyl;
• and
• X1 is selected from sulfonyl, sulfinyl, sulfonimidoyl, phosphonyl, phosphinate, thiophosphonyl, thiophosphinate, and phosphonamidate,
• or a pharmaceutically acceptable salt or solvate thereof.