Spironolactone Aqueous Compositions

A process for preparing a pharmaceutical composition, which comprises:

• (a) mixing in a first container a first composition comprising a hydrocolloid, an anti-foaming agent, a preservative, and water;
• (b) mixing in a second container a second composition comprising micronized spironolactone glycerin, and water;
• (c) transferring the second composition from the second container to the first container followed by mixing to obtain a third composition;
• and
• (d) adding a flavoring agent and water to the first container from step (c) to obtain a fourth composition;
• wherein the pharmaceutical composition comprises 5 mg/mL micronized spironolactone;
• and
• wherein the pharmaceutical composition comprises from 18 mg/mL to 24 mg/mL glycerin.