Back to results
US 2022/0313624 A1Published application
Sulfur (vi) fluoride compounds and methods for the preparation thereof
AssigneeThe Scripps Research Institute
InventorsJiajia DONG, K. Barry SHARPLESS, Jeffery W. KELLY, Aleksandra BARANCZAK, Wentao CHEN
Life of this patent
Estimating the term…
Abstract
Described herein are compounds comprising a biologically active organic core group with one to five —Z—(X1—S(O)(X2)F)m groups attached thereto, wherein Z is O, NR, or N; X1 is a covalent bond or CH2CH2; m can be 1 or 2 depending on the identity of Z; and X2 is O or NR. In some embodiments, the core group is an amino acid or a protein. In some embodiments the core group is a compound that has therapeutic activity toward a therapeutic target.
Claims24
A compound represented by Formula (I):
- YZX1—S(O)(X2)F)m]n (1)
- wherein:
- Y is a biologically active organic core group comprising one or more unsubstituted or substituted moiety selected from an aryl group, a heteroaryl group, a nonaromatic hydrocarbyl group, a nonaromatic heterocyclic group, to which each Z independently is covalently bonded;
- n is 1, 2, 3, 4 or 5;
- each Z independently is O, NR, or N;
- when Z is O, m is 1, X1 is a covalent bond, and the Z is covalently bonded to an aryl or heteroaryl moiety of Y;
- when Z is NR, m is 1, X1 is a covalent bond or CH2CH2;
- when Z is N, either (a) m is 2, and X1 is CH2CH2;
- or (b) m is 1, X1 is a covalent bond or CH2CH2, and the Z is a nitrogen in an aromatic or nonaromatic heterocyclic ring portion of core group Y;
- each X2 independently is O or NR;
- and
- each R independently comprises H or a substituted or unsubstituted group selected from an aryl group, a heteroaryl aryl group, a nonaromatic hydrocarbyl group, and a nonaromatic heterocyclic group.
9 more elements
A compound comprising:
- an amino acid;
- and
- an —SO2F group or —OSO2F group attached thereto.
A compound comprising:
- Y—Z—X1—SO2-Nu-Protein, or
- Y—SO2-Nu-Protein,
- wherein:
- Y is a biologically active organic core group comprising one or more unsubstituted or substituted moiety selected from an aryl group, a heteroaryl aryl group, a nonaromatic hydrocarbyl group, and a nonaromatic heterocyclic group, to which Z is covalently bonded;
- Z is O, NR, or N;
- when Z is O, X1 is a covalent bond, and Z is covalently bonded to an aryl or heteroaryl moiety of Y;
- when Z is NR, X1 is a covalent bond or CH2CH2;
- when Z is N, either (a) X1 is CH2CH2;
- or (b) X1 is a covalent bond or CH2CH2, and the Z is a nitrogen in an aromatic or nonaromatic heterocyclic ring portion of core group Y;
- R is H or a substituted or unsubstituted group selected from an aryl group, a heteroaryl aryl group, a nonaromatic hydrocarbyl group, and a nonaromatic heterocyclic group;
- Protein comprises a receptor protein;
- and
- Nu comprises a nucleophilic sidechain of a nucleophilic amino acid residue within a receptor site of the receptor protein.
10 more elements
Dependencies are inferred from the claim text.