Plant viral nucleic acid delivery particles and uses thereof
AssigneeCase Western Reserve University
InventorNicole F. Steinmetz
Life of this patent
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Abstract
A nanoparticle includes a plant virus or plant virus like particle (VLP), an exogenous therapeutic nucleic acid encapsulated within the plant virus or plant VLP, and one or more fusogenic peptides or cell penetrating peptides conjugated to an exterior surface of the plant virus or plant VLP.
Claims20
A nanoparticle comprising a plant virus or plant virus like particle (VLP), an exogenous therapeutic nucleic acid encapsulated within the plant virus or plant VLP, and one or more fusogenic peptides or cell penetrating peptides conjugated to an exterior surface of the plant virus or plant VLP.
A method of expressing a therapeutic nucleic acid in a mammal, comprising administering a plant virus particle composition to the mammal, the composition including a plant virus or plant virus-like particle (VLP), a therapeutic nucleic acid encapsulated within the plant virus or plant VLP, and one or more fusogenic peptides or cell penetrating peptides conjugated to an exterior surface of the plant virus or plant VLP.
The method of claim 33, the one or more fusongenic peptide or cell penetrating peptide comprising a L17E M-lycotoxin peptide.
Dependencies are inferred from the claim text.