Back to results
US 2022/0313600 A1Published application
Formulations of psma imaging agents
AssigneeClarity Pharmaceuticals Ltd
InventorsPaul Stephen DONNELLY, Nicholas Alan ZIA, Lawson Kyle SPARE, Ellen Marianne VAN DAM, Kevin Kar Weng KUAN
Life of this patent
Estimating the term…
Abstract
The present invention relates to formulations of radiolabeled compounds that are of use in radiotherapy and diagnostic imaging related to prostate specific membrane antigen (PSMA).
Claims21
An aqueous formulation for parenteral administration comprising a compound of Formula (I), or a salt thereof, complexed with a Cu ion:
- the formulation further comprising at least one of gentisic acid, ascorbic acid, L-methionine, pyridoxine or a salt thereof;
- or an aqueous formulation for parenteral administration comprising a compound of Formula (I), or a salt thereof, complexed with a Cu ion:
- the formulation further comprising a buffer solution.
(canceled)
A process for preparing a formulation comprising a compound of Formula (I) complexed with a Cu radioisotope,
- the process comprising the steps of:
- i) adding an amount of a compound of Formula (I) to an acetate buffer solution;
- ii) adding a solution of a Cu radioisotope in hydrochloric acid to the compound of Formula (I) and the acetate buffer;
- and
- iii) heating the mixture of step ii) for a time and under conditions for a complex of Formula (I) and the Cu radioisotope to form;
- or, process for preparing a formulation comprising a compound of Formula (I) complexed with a Cu radioisotope:
- the process comprising the steps of:
- i) adding an amount of a compound of Formula (I) to a phosphate buffer solution;
- ii) adding a solution of a Cu radioisotope in hydrochloric acid to the compound of Formula (I) and the phosphate buffer solution;
- and
- iii) allowing the mixture of step ii) to react for a time and under conditions for a complex of Formula (I) and the Cu radioisotope to form.
8 more elements
(canceled)
A process for purifying a compound of Formula (I) complexed with a Cu radioisotope:
- the process comprising the steps of:
- i) loading a solution of a compound of Formula (I) complexed with a Cu radioisotope on to a solid phase extraction cartridge;
- ii) eluting the compound of Formula (I) complexed with a Cu radioisotope with an eluent comprising water, ethanol and sodium chloride.
Dependencies are inferred from the claim text.