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US 2022/0306729 A1Published application
Neutralizing antibodies that bind to the zika virus domain iii envelope region
AssigneeThe Rockefeller University
InventorsDavide ROBBIANI, Michel NUSSENZWEIG
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Abstract
Antibodies to Zika virus (ZIKV) and dengue 1 virus (DENV1) are provided. The amino acid sequences of the antibodies may be modified. Methods for prophylaxis and/or therapy by administering the antibodies and combinations thereof are provided. Immunological detection methods using the antibodies are provided. Also provided are vaccine compositions which comprise peptides derived from ZIKV and DENV1.
Claims17
An isolated or recombinant antibody comprising (Z021):
- a heavy chain comprising:
- a CDR1 comprising GGSIDTYY (SEQ ID NO:6), a CDR2 comprising FYYSVDN (SEQ ID NO:7), and a CDR3 comprising ARNQPGGRAFDY (SEQ ID NO:8) (a Z021 heavy chain);
- and
- a light chain comprising:
- a CDR1 comprising QSVSNY (SEQ ID NO:9), a CDR2 comprising DTS, and a CDR3 comprising QERNNWPLTWT (SEQ ID NO:10) (a Z021 light chain).
2 more elements
Dependencies are inferred from the claim text.