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US 2022/0306587 A1Published application
Compounds and use thereof for the treatment of infectious diseases and cancer
AssigneeAc Bioscience
InventorsChristian AUCLAIR, Annette IVES
Life of this patent
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Abstract
The invention provides the imidazole, oxazole and thiazole compounds and use thereof in methods for treating a disease or a disorder, such as infectious diseases and cancer, wherein inhibition of sphingosine-1-phosphate lyase is beneficial to treat the disease or the disorder.
Claims21
A compound of Formula I
- or a phosphorylated derivatives thereof and/or a phosphoric acid esters thereof
- wherein
- Z is selected from the group consisting of O, S, and NH;
- Q is
- X is O or NR3;
- R1 is selected from the group consisting of ORA, NHOH, hydrogen, and C1-C5 alkyl;
- R2 is selected from the group consisting of hydrogen, 1,2,3,4-tetrahydroxybutyl, and —(CH2)n—OH, wherein n is 1 to 5;
- R3 is ORC or hydrogen;
- R4 is selected from the group consisting of hydrogen, 1,2,3,4-tetrahydroxybutyl, and —(CH2)n—OH, wherein n is 1 to 5;
- and
- each of RA and RC is hydrogen.
8 more elements
Dependencies are inferred from the claim text.