Ndufs2 subunit knockout human cell line
AssigneeVirginia Tech Intellectual Properties, Inc.
InventorsAloka B. BANDARA, David A. BROWN
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Abstract
Disclosed herein is a recombinant human cell line that does not express functional endogenous NADH dehydrogenase [ubiquinone] iron-sulfur protein 2 (NDUFS2). This knockout cell line can be used to advance the basic understanding of the NDUFS2 protein subunit in overall complex I assembly and function. Furthermore, this cell line can be used to test therapeutic agents to fix or bypass the dysfunctional complex I.
Claims12
A recombinant human cell line, wherein each cell of the recombinant human cell line has an inactivation mutation in a NADH dehydrogenase [ubiquinone] iron-sulfur protein 2 (NDUFS2) gene, wherein the human cell line does not express a functional NDUFS2 protein.
Dependencies are inferred from the claim text.