High throughput method for constructing and screening compound library and reaction device

A method for constructing and screening a high-throughput compound library comprising:

• (a) providing a reactor comprising n reaction chambers, wherein the reaction chambers are each independent and addressable, and the n reaction chambers constitute an addressable array of reaction chambers;
• (b) performing m each independent synthesis reactions in the n reaction chambers, and obtaining respective synthetic product in each of reaction chambers in which the synthesis reactions are carried out, thereby constructing and obtaining a compound library;
• wherein, the synthesis reaction comprises the following steps:
• (b1) in a reaction chamber, in an inert solvent, carrying out a 1, 3-dipolar cycloaddition reaction with a 1, 3-dipolar cyclization reagent and a reaction substrate containing terminal unsaturated bond, thereby forming a reaction product containing 1, 3-dipolar ring;
• and (c) optionally, adding activity test reagent into the reaction chambers where the synthesis reactions are carried out, respectively to carry out activity test, thereby carrying out activity screening on each synthetic product;
• wherein, n is a positive integer ≥10, and m is a positive integer ≤n and m≥10.