US 2022/0289657 A1 · COMPOSITION FOR PREVENTING OR TREATING BACTERIAL INFECTIOUS DISEASE COMPRISING 4-GINGEROL DERIVATIVE COMPOUND AS ACTIVE INGREDIENT

Abstract

The present invention relates to a 4-gingerol derivative compound, or a racemate, isomer, or pharmaceutically acceptable salt thereof, the compound being capable of inhibiting biofilm formation and production of virulence factors. The 4-gingerol derivative compound according to the present invention has binding affinity to RhlR and corresponding RhlR antagonism activity that are significantly improved, and therefore can effectively inhibit biofilm formation and production of virulence factors. Furthermore, various bacterial infectious diseases caused by biofilms can be fundamentally prevented or treated by using a pharmaceutical composition comprising the 4-gingerol derivative compound, or a racemate, isomer, or pharmaceutically acceptable salt thereof as an active ingredient.

Claims18

Dependent claims

A gingerol derivative compound represented by Formula 1 below, a racemate, enantiomer or pharmaceutically acceptable salt thereof:

In Formula 1,
X and Y are the same or different from each other, and each independently any one selected from hydrogen, a halogen group, an alkyl group, a hydroxyl group, O—R′, and NR′R′ (R′ is a C1-C2 alkyl group), R1 is a C1-C3 alkyl group,
the “.” represents a single bond or a double bond (however, when the “.” is a double bond, OR2 is O, and when the “.” is a single bond, OR2 is OH), and
L is any one selected from a single bond, a double bond and a triple bond.

1 more element

Dependencies are inferred from the claim text.

Facts

Application

17/637,565Filed 21 Aug 2020

Priority

KR 10-2019-010352223 Aug 2019

Published

15 Sep 2022

Term ends

Not estimatedThe source records don’t support an estimate.

Classification16 codes

C07C 49/255
Unsaturated compounds containing keto groups bound to acyclic carbon atoms: containing ether groups, [IMAGE cpc-sch-C07C-0958.gif] groups,[IMAGE…
A61K 31/045
Medicinal preparations containing organic active ingredients: hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
A61K 31/085
Ethers or acetals: having an ether linkage to aromatic ring nuclear carbon
A61K 31/12
Medicinal preparations containing organic active ingredients: ketones

Composition for preventing or treating bacterial infectious disease comprising 4-gingerol derivative compound as active ingredient

Life of this patent

Composition for preventing or treating bacterial infectious disease comprising 4-gingerol derivative compound as active ingredient

Life of this patent

Abstract

Claims18