US 2022/0288084 A1 · NUCLEOSIDE DERIVATIVE FOR PREVENTING AND TREATING INFLAMMATION AND APPLICATION THEREOF

Abstract

The present invention provides a nucleoside derivative for preventing and treating inflammation and an application thereof in the preparation of a drug for preventing and treating inflammatory diseases. The nucleoside derivative for preventing and treating inflammation provided by the present invention can significantly ameliorate conditions of pancreatitis, hepatitis, arthritis and the like, ameliorate organ injury and inflammatory indexes, and have better effects than positive control drug, indometacin. Compared with the conventional anti-inflammatory drugs, aspirin, ibuprofen, indomethacin, phenylbutazone, diclofenac, piroxicam and glucocorticoids, the nucleoside derivative for preventing and treating inflammation provided by the present invention has the advantage of significantly fewer side effects.

Claims9

Dependent claims

A nucleoside derivative for preventing and treating inflammation, wherein the structure formula of the derivative is represented by formula (I)˜formula (IV), or the derivative is a pharmaceutically acceptable salt of a compound of formula (I)˜formula (IV),

in formula (I)˜formula (IV), R1 is H, alkyl, heterocyclyl, alkyl substituted with an oxygen atom, a sulfur atom, a nitrogen atom or halogen, an ester group, amido or amino;
R3 and R4 are alkyl, heterocyclyl, alkyl substituted with an oxygen atom, a sulfur atom, a nitrogen atom or halogen;
R2 and R5 are O or S, X and Y are N or C, and Z is halogen.

Dependencies are inferred from the claim text.

Facts

Application

17/605,676Filed 25 Mar 2020

Priority

CN 201910239233.X27 Mar 2019

Published

15 Sep 2022

Term ends

Not estimatedThe source records don’t support an estimate.

Classification13 codes

A61K 31/522
Purines, e.g. adenine: having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
A61K 31/513
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim: having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
A61P 1/16
Drugs for disorders of the alimentary tract or the digestive system: for liver or gallbladder disorders, e.g. hepatoprotective agents,…
A61P 1/18
Drugs for disorders of the alimentary tract or the digestive system: for pancreatic disorders, e.g. pancreatic enzymes

Nucleoside derivative for preventing and treating inflammation and application thereof

Life of this patent

Nucleoside derivative for preventing and treating inflammation and application thereof

Life of this patent

Abstract

Claims9