# US 2022/0284391 A1 · Activity based enzyme inventory management

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- Number: US 2022/0284391 A1
- Document ID: US20220284391A1
- Status: Published application
- Kind: A1
- Application number: 17/632,609
- Filed: 2020-09-10
- Published: 2022-09-08
- Earliest claimed: 2019-09-11
- Assignees: BASF SE
- Applicants: BASF SE
- Inventors: Stefan Fischer; Jesper Nielsen; Simeon Sauer; Grit Baier
- Web page: https://patentgrep.com/patent/US20220284391A1

## CPC

- G06Q 10/0838: {Historical data}
- G01K 3/04: in respect of time
- G06Q 10/08: Logistics, e.g. warehousing, loading or distribution; Inventory or stock management
- G06Q 10/0832: Special goods or special handling procedures, e.g. handling of hazardous or fragile goods
- G06Q: INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL OR SUPERVISORY PURPOSES; SYSTEMS OR METHODS SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL OR SUPERVISORY PURPOSES, NOT OTHERWISE PROVIDED FOR
- G01K: MEASURING TEMPERATURE; MEASURING QUANTITY OF HEAT; THERMALLY-SENSITIVE ELEMENTS NOT OTHERWISE PROVIDED FOR (radiation pyrometry G01J5/00)

## Abstract

The present invention relates to a computer-implemented method for activity based enzyme formulation management of an enzyme formulation comprising (i) receiving input data, preferably via an input unit (10), of at least one storage segment data defined by at least temperature and storage duration and an initial enzyme activity value of said enzyme Predicted degradation formulation; (ii) determining, specifically calculating, a remaining activity value of the enzyme formulation based on the storage segment data and the initial enzyme activity value via a processing unit (20); (iii) providing a remaining activity value for the enzyme formulation, preferably via an output unit (30), and (iv) managing said enzyme formulation based on the remaining activity value of step (iii), said managing preferably comprising at least one of—providing a dosage recommendation based on the remaining activity value of the enzyme formulation, preferably via an output unit (30);—providing a residual shelf life indicator for said enzyme formulation based on the remaining activity value of the enzyme formulation; —automated adjustment of a dosage of the enzyme formulation by controlling of a dosing equipment; and/or—eliciting an order of a batch of enzyme formulation if the remaining activity value is indicative of the total enzyme activity in the enzyme formulation being below a pre- determined threshold value. The present invention also relates to an apparatus for activity based enzyme formulation management of an enzyme formulation, comprising: —an input unit (10) configured to receive a data input, preferably a user interface, wherein the data input comprises storage segment data defined by at least temperature and duration and an initial enzyme activity value of said enzyme formulation; —a processing unit (20), preferably a processing unit comprising at least one processor, configured, specifically by programming, to determine, specifically to calculate, a remaining activity value of the enzyme formulation based on the storage segment data and the initial enzyme activity value; and—an output unit (30) configured to output the remaining activity value for the enzyme formulation to the user and/or to a data interface.; and to a system comprising said apparatus. The present invention further relates to methods, computer programs, data carriers, and uses related to the aforesaid method, apparatus, and system.

## Claims

### Claim 1

A computer-implemented method for activity based enzyme formulation management of an enzyme formulation comprising
(i) receiving input data of at least one storage segment data defined by at least temperature and storage duration and an initial enzyme activity value of said enzyme formulation;
(ii) determining a remaining activity value of the enzyme formulation based on the storage segment data and the initial enzyme activity value via a processing unit (20);
(iii) providing a remaining activity value for the enzyme formulation, and (iv) managing said enzyme formulation based on the remaining activity value of step (iii), said managing preferably comprising at least one of
providing a dosage recommendation based on the remaining activity value of the enzyme formulation;
providing a residual shelf life indicator for said enzyme formulation based on the remaining activity value of the enzyme formulation;
automated adjustment of a dosage of the enzyme formulation by controlling of a dosing equipment; and/or
eliciting an order of a batch of enzyme formulation if the remaining activity value is indicative of the total enzyme activity in the enzyme formulation being below a pre-determined threshold value.

### Claim 2 (depends on 1)

The computer-implemented method of claim 1, wherein the at least one storage segment data is determined based on sensor data.

### Claim 3 (depends on 2)

The computer-implemented method of claim 2, wherein the sensor data is received from a sensor in close proximity or within the enzyme formulation during at least one storage segment.

### Claim 4 (depends on 3)

The computer-implemented method of claim 3, wherein said sensor is located within the same storage space as the enzyme formulation and/or is attached to a packaging, a pallet, or an outer shell of a container of the enzyme formulation.

### Claim 5 (depends on 2)

The computer-implemented method of claim 2, wherein the sensor data is corrected, specifically by one or both of the input unit and the processing unit, by calculating a temperature within the enzyme formulation; or wherein the sensor data is received from at least one sensor located within the enzyme formulation.

### Claim 6 (depends on 1)

The computer-implemented method of claim 1, wherein said enzyme formulation is exposed to a multitude of non-identical storage segments differing at least in temperature.

### Claim 7 (depends on 1)

The computer-implemented method of claim 1, wherein at the temperature of at least one storage segment is not controlled.

### Claim 8 (depends on 1)

The computer-implemented method of claim 1, wherein in step (ii) the remaining activity value of the enzyme formulation is calculated based on a model comprising a time-varying temperature parameter.

### Claim 9 (depends on 1)

The computer-implemented method of claim 1, wherein said model comprises at least one temperature-dependent Weibull type equation.

### Claim 10

An apparatus (110) for activity based enzyme formulation management of an enzyme formulation, comprising:
an input unit (10) configured to receive a data input, preferably a user interface, wherein the data input comprises storage segment data defined by at least temperature and duration and an initial enzyme activity value of said enzyme formulation;
a processing unit (20) configured to determine, a remaining activity value of the enzyme formulation based on the storage segment data and the initial enzyme activity value; and
an output unit (30) configured to output the remaining activity value for the enzyme formulation to the user and/or to a data interface.

### Claim 11 (depends on 10)

The apparatus according to claim 10, further configured to perform at least one of the following:
output the value of the remaining activity value of the enzyme formulation via the output unit;
determine by the processing unit and output via the output unit a residual shelf life value of the enzyme formulation;
determine by the processing unit and output via the output unit a dosage instruction for the enzyme formulation; and/or
automatically elicit an order of an an additional batch of enzyme formulation if the remaining activity value indicates that the total enzyme activity in the enzyme formulation is below a pre-determined threshold value.

### Claim 12 (depends on 11)

The apparatus according to claim 11, further configured to:
download relevant information including quality information, regulatory information, safety data, and/or technical documents;
order enzyme formulations; and/or
provide a user-feedback including usability, information content and/or enzyme formulation outcome.

### Claim 13 (depends on 10)

The apparatus according to claim 10, wherein said apparatus is a washing machine and further comprises
a container unit configured to store an enzyme formulation; and
a dosage unit configured to dose an amount of the enzyme formulation comprised in the container unit during a wash cycle based on the remaining activity value determined by the processing unit.

### Claim 14 (depends on 10)

A system (100) for providing activity based enzyme inventory management of an enzyme formulation, comprising:
an apparatus (110) according to claim 10; and
a web server (140) configured to interface with a user via a webpage served by the web server and/or via an application program;
wherein the system is configured to provide a graphical user interface (GUI) to a user by the webpage and/or the application program.

### Claim 15 (depends on 1, 14)

The system of claim 14, wherein said web server serves to the user at least one of
a storage segment data, defined by at least temperature and duration, and an initial enzyme activity value of said enzyme formulation;
the parameters required for determining a remaining activity value of an enzyme formulation and an initial enzyme activity value of said enzyme formulation; and
a remaining activity value of the enzyme formulation, preferably determined according to the method according to claim 1.

### Claim 16 (depends on 1)

A computer program comprising instructions which, when the program is executed by a processor of the apparatus, cause the apparatus and/or the system to perform the method of claim 1.

### Claim 17 (depends on 1)

A computer-readable storage medium comprising instructions which, when executed by an apparatus cause the apparatus and/or the system to perform the method of claim 1.

### Claim 18 (depends on 1)

The computer-implemented method according to claim 1 for determining a remaining activity value of an enzyme formulation in a washing machine.

### Claim 19

(canceled)