Back to results
US 2022/0283141 A1Published application
Method
AssigneeOxford Nanopore Technologies PLC
InventorsLakmal Jayasinghe, John Joseph Kilgour, Neil Roger Wood
Life of this patent
Estimating the term…
Abstract
The invention relates to a novel method of producing hetero-oligomeric pores. The invention also relates to hetero-oligomeric pores produced using the method and polynucleotide characterisation using the hetero-oligomeric pores.
Claims22
-29. (canceled)
A method of characterising a target analyte comprising:
- (a) contacting the analyte with a hetero-oligomeric transmembrane pore such that the polynucleotide moves through the pore wherein the pores comprises a first monomer and a second monomer, wherein the first monomer is different from the second monomer, and wherein the first monomer comprises a variant of any one of SEQ ID NOs:
- 2, 4-7, 31, or 32;
- and
- (b) taking one or more measurements as the analyte moves with respect to the pore, wherein the measurements are indicative of one or more characteristics of the analyte, and thereby characterising the target analyte.
1 more element
-44. (canceled)
Dependencies are inferred from the claim text.