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US 2022/0282236 A1Published application
Creatinine deiminase and uses thereof
OwnerHelmut SCHWABinventor
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Abstract
The present invention relates broadly to the field of creatinine determination. In particular, it provides a novel creatinine deiminase characterized by novel nucleic acid and amino acid sequences and superior enzymatic activity. It also provides uses of this creatinine deiminase, including assays for determining the amount of creatinine in a sample. These can be useful inter alia for the detection of kidney disease.
Claims18
1-15. (canceled)
A recombinant cell comprising a nucleic acid encoding the creatinine deiminase polypeptide of SEQ ID NO:
- 4 or a polypeptide having an amino acid sequence at least 95% identical to SEQ ID NO:
- 4 and having creatinine deiminase activity, wherein the recombinant cell is not a Tissierella creatinini cell.
A vector comprising a nucleic acid comprises nucleotides 115 to 1374 of SEQ ID NO:
- 3 or a nucleotide sequence at least 90% identical to positions 115 to 1374 of SEQ ID NO:
- 3.
Dependencies are inferred from the claim text.