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US 2022/0280531 A1Published application
Enzymatic process for obtaining 17 alpha-monoesters of cortexolone and/or its 9,11-dehydroderivatives
AssigneeCassiopea S.P.A.
InventorsMauro AJANI, Luigi MORO
Life of this patent
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Abstract
The present invention refers to a new enzymatic process for obtaining 17α-monoesters of cortexolone and/or its 9,11-dehydroderivatives starting from the corresponding 17α,21-diesters which comprises an enzymatic alcoholysis reaction. Furthermore, the present invention refers to new crystalline forms of cortexolone-17α-propionate and 9,11-dehydro-cortexolone 17α-butanoate.
Claims24
1-20. (Canceled)
A topical composition comprising crystalline cortexolone-1760 -propionate in at least two crystalline forms selected from the group consisting of crystalline Form I, crystalline Form II, crystalline Form III, and crystalline Form IV.
Dependencies are inferred from the claim text.