# US 2022/0276221 A1 · Depth Filtration Device for Separating Specimen Phases

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- Number: US 2022/0276221 A1
- Document ID: US20220276221A1
- Status: Published application
- Kind: A1
- Application number: 17/749,587
- Filed: 2022-05-20
- Published: 2022-09-01
- Earliest claimed: 2015-09-01
- Assignees: Becton, Dickinson and Company
- Applicants: Becton, Dickinson and Company
- Inventors: Kishore K. Bokka Srinivasa Rao; Daniel J. Marchiarullo; Milan Ivosevic
- Web page: https://patentgrep.com/patent/US20220276221A1

## CPC

- B01D 15/10: characterised by constructional or operational features
- G01N 33/491: {by separating the blood components (G01N15/05 takes precedence)}
- A61B 5/150022: {for capillary blood or interstitial fluid}
- A61B 5/150343: {Collection vessels for collecting blood samples from the skin surface, e.g. test tubes, cuvettes (sampling from within body cavities A61B5/150015, A61B5/150045)}
- A61B 5/150358: {Strips for collecting blood, e.g. absorbent}
- B01D 15/102: {Process control, e.g. determination or optimization of process parameters; Programmable logic control [PLC]}
- B01L 3/502: {with fluid transport, e.g. in multi-compartment structures}
- B01L 3/5023: {with a sample being transported to, and subsequently stored in an absorbent for analysis}
- B01L 2200/026: Fluid interfacing between devices or objects, e.g. connectors, inlet details
- B01L 2200/0652: Sorting or classification of particles or molecules
- B01L 2300/042: Caps; Plugs
- B01L 2300/048: enabling gas exchange, e.g. vents
- B01L 2300/0609: Holders integrated in container to position an object
- B01L 2300/0681: Filter
- B01L 2300/0838: Capillaries
- B01L 2300/087: Multiple sequential chambers
- B01L 2300/123: Flexible; Elastomeric
- B01L 2300/14: Means for pressure control
- B01L 2300/161: Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
- B01L 2400/0406: capillary forces
- B01L 2400/0481: squeezing of channels or chambers
- B01L 2400/049: vacuum
- B01D: SEPARATION (separating solids from solids by wet methods B03B, B03D; by pneumatic jigs or tables B03B; by other dry methods B07; magnetic or electrostatic separation of solid materials from solid materials or fluids, separation by high-voltage electric fields B03C; centrifuges, vortex apparatus B04; presses per se for squeezing-out liquid from liquid-containing material B30B9/02; treatment of water C02F, e.g. softening by ion-exchange C02F1/42; {arrangements of air intake cleaners in gas turbine plants F02C7/05} ; arrangements or mounting of filters in air-conditioning, air-humidification or ventilation F24F13/28)
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)
- B01L: CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE

## Abstract

The present disclosure provides a biological fluid collection device, such as a blood collection device, that is adapted to receive a multi-component blood sample having a cellular portion and a plasma portion and quickly, efficiently and cost-effectively separate the plasma portion from the sample. A pressure gradient can be applied across a separation member to facilitate movement of the plasma portion ahead of the cellular portion. The present disclosure allows for both passive and active plasma separation and dispensing.

## Claims

### Claim 1

A device for separation of a biological sample into a first phase and a second phase, said device comprising:
a holder including an inlet and an outlet, said inlet configured for receiving the biological sample;
at least one lateral flow strip cooperating with the holder for separating the biological sample into the first phase and the second phase; and
a member for creating a pressure gradient across the lateral flow strip to increase a rate of movement of the biological sample through the lateral flow strip such that the first phase exits the flow strip prior to the second phase.

### Claim 2 (depends on 1)

The device of claim 1, wherein the at least one lateral flow strip comprises a plurality of lateral flow strips stacked one upon another.

### Claim 3 (depends on 1)

The device of claim 1, wherein the lateral flow strip has a trapezoidal shape having a large base and a small base and wherein the large base is positioned adjacent the inlet of the holder and the small base is positioned adjacent the outlet of the holder.

### Claim 4

A device for the collection of a biological sample and separation of the biological sample into a first phase and a second phase, said device comprising:
a collection chamber having an inlet for collecting the biological sample via venous pressure;
a separation chamber associated with the collection chamber;
a separator located within the separation chamber for separating the biological sample into the first phase and the second phase;
a cannula having a first end associated with the separation chamber; and
a vacuum tube associated with the separation chamber via a second end of the cannula, said vacuum tube configured for applying a pressure gradient across the separator to increase a rate of movement of the biological sample through the separator to facilitate separation of the first phase from the second phase and to cause the first phase to enter into the vacuum tube via the cannula.

### Claim 5 (depends on 4)

The device of claim 4, wherein the separator comprises at least one filter formed of a fibrous material.

### Claim 6 (depends on 4)

The device of claim 4, wherein the collection chamber and the separation chamber are separable from the vacuum tube and wherein after separation of the sample and collection of the first phase into the vacuum tube, the collection chamber and separation chamber can be removed from the vacuum tube.

### Claim 7 (depends on 4)

The device of claim 4, wherein the collection chamber includes a luer lock for connecting the collection chamber to a biological collection system.