Improved Retinal Organoids And Methods Of Making The Same
AssigneeNewcells Biotech Limited
InventorsValeria CHICHAGOVA, Lyle ARMSTRONG, Majlinda LAKO
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Abstract
The present invention relates to methods for making in vitro retinal cultures, tissue, or retinal organoids, from pluripotent cells as well as the improved synthetic retinal tissue and retinal organoids themselves. It also relates to retinal organoids that replicate in vitro many characteristics of the retina (e.g., human or mammalian), and methods of using this retinal organoid to study disease and to identify therapeutic agents for the treatment of retinal diseases and disorders.
Claims33
A pluripotent stem cell-derived, in vitro generated, retinal tissue comprising retinal cells and microglial cells.
A method for obtaining a retinal tissue or a retinal organoid comprising co-culturing microglial or microglial progenitor cells and the retinal organoid under conditions which allow the microglial cells to integrate into the organoid.
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Dependencies are inferred from the claim text.