Back to results
US 2022/0265845 A1Published application
Aminothiolester compounds and uses thereof
AssigneeAdvanced Biodesign
InventorsIsmail CEYLAN, Guillaume MARTIN, Mileidys PEREZ, Axelle BERROU
Life of this patent
Estimating the term…
Abstract
The present invention relates to novel aminoesters compounds or its pharmaceutically acceptable salts or optical isomers, racemates, diastereoisomers, enantiomers or tautomers. The present invention also relates to their process of preparation and to these compounds for use as a medicament, in particular for the treatment or the prevention of cancer. The present invention further relates to an antibody drug conjugate comprising such compounds.
Claims16
A compound of formula (I):
- in which:
- X is an atom chosen from O or S;
- R1 and R2 identical or different are independently chosen from:
- linear or branched (C1-C7)alkyl, linear or branched (C2-C7)alkenyl, aryl, heteroaryl, CHR5CHR6OR4 and (CHR5), OR4,
- said aryl and heteroaryl being optionally substituted by one or more substituents chosen from:
- linear or branched (C1-C7)alkyl, halogen, NO2 and CONH2;
- v is chosen from 2 to 4;
- R3 is chosen from linear or branched (C1-C7)alkyl, (C1-C7)alkyl —CO2Z and linear or branched (C1-C7)alkyl-NY1Y2;
- said linear or branched (C1-C7)alkyl-NY1Y2 being optionally substituted by (C1-C7)alkyl —CO2Z;
- R4 is chosen from:
- H, linear or branched (C2-C7)alkyl, linear or branched (C2-C7)alkenyl, —CONR7R8, aryl, heteroaryl, (C2-C7)cycloalkyl, linear or branched —(C1-C7)alkyl-aryl and linear or branched —(C1-C7)alkyl-heteroaryl;
- said aryl, (C2-C7)cycloalkyl, and heteroaryl being optionally substituted by one or more substituents chosen from:
- halogen, linear or branched (C1-C7)alkyl optionally substituted by one or more halogen atom, linear or branched (C1-C7)alkoxy optionally substituted by one or more halogen atom, —COOH, aryl, —NRR′, —NO2, or said aryl and heteroaryl being optionally fused to form an heterocycloalkyl;
- R5 and R6 identical or different are independently chosen from:
- H and linear or branched (C1-C7)alkyl, or
- R5 and R6 are linked together to form with the carbon atoms to which they are attached a cycloalkyl, aryl or heteroaryl, or
- R5 is H and R1 and R6 are linked together to form with the nitrogen atom linked to R1 an heterocycloalkyl or heteroaryl, or
- R6 is H and R1 and R5 are linked together to R1 to form with the nitrogen atom linked to R1 an heterocycloalkyl;
- R7 is —(C1-C3)alkyl;
- R8 is —(C1-C3)alkylNRR′;
- R and R′ identical or different, are independently chosen from H and linear or branched (C1-C7)alkyl,
- Y1 and Y2 identical or different are independently chosen from H and —CO—(C1-C7)alkyl;
- Z is chosen from H and linear or branched (C1-C7)alkyl;
- and in which, at least one of R1 and R2 is CHR5CHR6OR4 or (CHR5), OR4 when X is S and R3 is linear or branched (C1-C7)alkyl;
- or its pharmaceutically acceptable salts or optical isomers, racemates, diastereoisomers, enantiomers or tautomers.
22 more elements
(canceled)
Dependencies are inferred from the claim text.