# US 2022/0264875 A1 · Multifunctional natural protectant systems with hydroxyacetophenone > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2022/0264875 A1 - Document ID: US20220264875A1 - Status: Published application - Kind: A1 - Application number: 17/650,417 - Filed: 2022-02-09 - Published: 2022-08-25 - Earliest claimed: 2021-02-15 - Assignees: Lincoln Manufacturing Company, Inc. - Applicants: Lincoln Manufacturing Inc. - Inventors: Patrick Jay LUTZ; Peter HORNISH - Web page: https://patentgrep.com/patent/US20220264875A1 ## CPC - A01N 35/04: containing aldehyde or keto groups, or thio analogues thereof, directly attached to an aromatic ring system, e.g. acetophenone; Derivatives thereof, e.g. acetals - A01N 25/22: containing ingredients stabilising the active ingredients - A01N 25/24: containing ingredients to enhance the sticking of the active ingredients - A01N 31/02: Acyclic compounds - A01P 1/00: Disinfectants; Antimicrobial compounds or mixtures thereof - A61P 31/00: Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics - A61P 31/04: Antibacterial agents - A01N: PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF (preservation of food or foodstuff A23); BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES (preparations for medical, dental or toiletry purposes which kill or prevent the growth or proliferation of unwanted organisms A61K); PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS - A01P: BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS - A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS ## Abstract The present invention relates to the use of multifunctional protectants comprising (i) hydroxyacetophenone with (ii) at least one of natural 1,3-propanediol and a mastic extract to protect a formulation from biodegradation. The present invention also relates to the use of a protectant comprising (i) hydroxyacetophenone with (ii) at least one of vitamin B5, vitamin C, and vitamin E to protect a formulation from biodegradation. ## Claims ### Claim 1 A product comprising an effective amount of (a) 4-hydroxyacetophenone and (b) at least one of a mastic extract and 1,3-propanediol to inhibit microbial growth in the product, wherein, when the product includes 4-hydroxyacetophenone and 1,3-propanediol, the product does not contain 3-phenylpropanol, 1,2-hexanediol, 1,2-octanediol, or ethylhexylglycerin. ### Claim 2 (canceled) ### Claim 3 (depends on 1) The product of claim 1, wherein the product comprises mastic extract, and the mastic extract is selected from mastic oil, mastic water, and any combination of any of the foregoing. ### Claim at position 4 4-8. (canceled) ### Claim 9 (depends on 1) The product of claim 1, wherein the product comprises 1,3-propanediol, and the weight ratio of 4-hydroxyacetophenone and 1,3-propanediol is no more than 1:3. ### Claim 10 (canceled) ### Claim 11 (depends on 1) The product of claim 1, wherein the product is substantially free of parabens, formaldehyde donors, and isothiazolinones. ### Claim 12 (canceled) ### Claim 13 (depends on 1) The product of claim 1, wherein the product comprises from about 0.001 to about 10% by weight of 4-hydroxyacetophenone and from about 0.001 to about 10% by weight of the 1,3-propanediol, based upon 100% total weight of the product. ### Claim at position 10 14-25. (canceled) ### Claim 26 (depends on 1) The product of claim 1, wherein the product further comprises at least one of vitamin B5, vitamin C, and vitamin E. ### Claim 27 (depends on 26) The product of claim 26, wherein the product comprises an effective amount of at least one of vitamin B5, vitamin C, and vitamin E to suppress degradation of 4-hydroxyacetophenone. ### Claim at position 13 28-32. (canceled) ### Claim 33 (depends on 26) The product of claim 26, wherein the product comprises from about 0.001 to about 2% by weight of the at least one of vitamin B5, vitamin C, and vitamin E, based upon 100% total weight of the product. ### Claim 34 (depends on 26) The product of claim 26, wherein the product does not contain (a) a glycerol ester of an alkane carboxylic acid or (b) an oligoglycerol ester of an alkane carboxylic acids. ### Claim at position 16 35-36. (canceled) ### Claim 37 (depends on 1) The product of claim 1, wherein the product is a personal care product. ### Claim 38 (canceled) ### Claim 39 A concentrate comprising (a) 4-hydroxyacetophenone and (b) at least one of a mastic extract and 1,3-propanediol. ### Claim 40 (canceled) ### Claim 41 (depends on 39) The concentrate of claim 39, further comprising at least one of vitamin B5, vitamin C, and vitamin E. ### Claim at position 22 42-44. (canceled) ### Claim 45 (depends on 41) The concentrate of claim 41, wherein the concentrate comprises (a) from about 10 to about 20% by weight of 4-hydroxyacetophenone, (b) from about 60 to about 80% by weight of 1,3-propanediol, and (c) from about 1 to about 5% by weight of at least one of vitamin B5, vitamin C, and vitamin E. ### Claim 46 (depends on 45) The concentrate of claim 45, wherein the concentrate consists of (a) 20% by weight of 4-hydroxyacetophenone, (b) 1% by weight of vitamin B5, and (b) 79% by weight of 1,3-propanediol. ### Claim 47 A concentrate comprising (a) 4-hydroxyacetophenone and (b) at least one of vitamin B5, vitamin C, and vitamin E. ### Claim at position 26 48-50. (canceled) ### Claim 51 (depends on 39) The concentrate of claim 39, wherein the concentrate consists of (a) from about 10% to about 30% by weight of 4-hydroxyacetophenone and (b) from about 70% to about 90% by weight of 1,3-propanediol. ### Claim 52 (depends on 51) The concentrate of claim 51, wherein the concentrate consists of (a) about 20% by weight of 4-hydroxyacetophenone and (b) about 80% by weight of 1,3-propanediol. ### Claim 53 A product comprising an effective amount of (a) 4-hydroxyacetophenone, (b) 1,3-propanediol, and (c) ethylhexylglycerin to inhibit microbial growth in the product, wherein the product does not contain 3-phenylpropanol. ### Claim 54 (depends on 53) The product of claim 53, wherein the product does not contain 1,2-hexanediol or 1,2-octanediol. ### Claim 55 (depends on 53) The product of claim 53, wherein the weight ratio of 4-hydroxyacetophenone and 1,3-propanediol is no more than 1:3. ### Claim 56 (canceled) ### Claim 57 (depends on 53) The product of claim 53, wherein the product is substantially free of parabens, formaldehyde donors, and isothiazolinones. ### Claim 58 (canceled) ### Claim 59 (depends on 53) The product of claim 53, wherein the product comprises from about 0.001 to about 10% by weight of 4-hydroxyacetophenone and from about 0.001 to about 10% by weight of the 1,3-propanediol, based upon 100% total weight of the product. ### Claim 60 (canceled) ### Claim 61 (depends on 53) The product of claim 53, wherein the weight ratio of 4-hydroxyacetophenone to 1,3-propanediol ranges from about 5:95 to about 30:50. ### Claim 62 (canceled) ### Claim 63 (depends on 53) The product of claim 53, wherein the weight ratio of 4-hydroxyacetophenone to ethylhexylglycerin ranges from about 10:1 to about 3:1. ### Claim 64 (depends on 63) The product of claim 63, wherein the product further comprises at least one of vitamin B5, vitamin C, and vitamin E. ### Claim 65 (depends on 64) The product of claim 64, wherein the product comprises an effective amount of at least one of vitamin B5, vitamin C, and vitamin E to suppress degradation of 4-hydroxyacetophenone. ### Claim 66 (depends on 39) The concentrate of claim 39, wherein (i) the concentrate comprises (a) 4-hydroxyacetophenone, (b) 1,3-propanediol, and (c) ethylhexylglycerin, and (ii) the concentrate does not contain 3-phenylpropanol. ### Claim 67 (depends on 66) The concentrate of claim 66, wherein the concentrate comprises from about 60 to about 80% by weight of 1,3-propanediol, from about 10 to about 25% by weight of 4-hydroxyacetophenone, and from about 5 to about 15% by weight of ethylhexylglycerin, based upon 100% total weight of concentrate. ### Claim 68 (depends on 66) The concentrate of claim 66, wherein the concentrate comprises from about 60 to about 80% by weight of 1,3-propanediol, from about 10 to about 20% by weight of 4-hydroxyacetophenone, and from about 1 to about 10% by weight of ethylhexylglycerin, based upon 100% total weight of concentrate. ### Claim 69 (depends on 6) The concentrate of claim 6, further comprising at least one of vitamin B5, vitamin C, and vitamin E. ### Claim 70 (canceled) ### Claim 71 (canceled) ### Claim 72 (depends on 1) A method of killing and/or inhibiting the growth of microorganisms on a substrate comprising applying an effective amount of a product of claim 1. ### Claim at position 49 73-79. (canceled)