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US 2022/0259138 A1Published application
Pleuromutilin salicylic acid ester with antibacterial activity and a method of preparing the same
AssigneeShaanxi University of Science and Technology
InventorsQianqian ZHAO, Liang XIN, Jingyi LI, Ruina BIAN, Dan YANG, Liang QI, Bin TIAN, Jian ZHA, Wenbo YAO, Gennian MAO, Han LI, Chunyang SHI, Yongbo WANG, Jingwen XU
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Abstract
A compound with anti-drug resistant bacteria activity having the following formula (I): is disclosed. The methods of preparing the compound of formula (I) are also disclosed.
Claims17
A compound having the following formula (I):
The method of claim 2, wherein the reaction of the compound of formula (II) with the compound of formula (III) comprises the following steps:
- placing the compound of formula (II) and the compound of formula (III), in a molar ratio of 1:1 to 1:1.3, in a reactor;
- adding an organic solvent and a catalytic amount of triethylamine under a nitrogen atmosphere to obtain a reaction mixture;
- heating the reaction mixture at 20-50° C. for 4-8 hours;
- concentrating the reaction mixture and extracting with ethyl acetate to obtain a crude product;
- and
- purifying the crude product on a fresh silica gel chromatography column with petroleum ether and ethyl acetate as an eluent to obtain the compound of formula (I).
3 more elements
(canceled)
Dependencies are inferred from the claim text.