Immunomodulatory compositions and methods of using
AssigneeUniversity of Louisville Research Foundation, Inc.
InventorsKevin Joseph Sokoloski, V Douglas Landers
Life of this patent
Estimating the term…
Abstract
Immunomodulatory compositions that include at least one alphavirus capsid protein and methods of using such immunomodulatory compositions. In one aspect, methods of immunomodulating IL-1/TLR signaling in a cell are provided. Such methods typically include contacting the cell with an alphavirus capsid protein or a portion thereof, thereby immunomodulating IL-1/TLR signaling in the cell.
Claims22
A method of immunomodulating IL-1/TLR signaling in a cell, comprising:
- contacting the cell with an alphavirus capsid protein or a portion thereof, thereby immunomodulating IL-1/TLR signaling in the cell.
A method of reducing the innate immune response in an individual receiving a therapeutic, comprising:
- delivering an alphavirus capsid protein or a portion thereof to the individual;
- and
- delivering the therapeutic to the individual,
- thereby reducing the innate immune response in the individual prior to the delivery of the therapeutic.
A method of screening for compounds that inhibit the infection of a host cell by an alphavirus, comprising:
- contacting an alphavirus capsid protein or a portion thereof and an IRAK1 protein or a portion thereof with a test compound,
- wherein a test compound that inhibits the binding between an alphavirus capsid protein or a portion thereof and an IRAK1 protein or a portion thereof or reduces the amount of alphavirus capsid protein or a portion thereof that is bound to an IRAK1 protein or a portion thereof is indicative of a compound that inhibits the infection of a host cell by an alphavirus.
A method of screening for compounds that inhibit the innate immune system in an individual, comprising:
- contacting an IRAK1 protein or a portion thereof with a test compound,
- wherein a compound that binds to the IRAK1 protein or the portion thereof is indicative of a compound that inhibits the innate immune system in an individual.
A method of screening for compounds that inhibit the infection of a host cell by an alphavirus, comprising:
- contacting an alphavirus capsid protein or a portion thereof and a protein or a portion thereof from Table 1 with a test compound,
- wherein a test compound that inhibits the binding between an alphavirus capsid protein or a portion thereof and a protein or a portion thereof from Table 1 or reduces the amount of alphavirus capsid protein or a portion thereof that is bound to a protein or a portion thereof from Table 1 is indicative of a compound that inhibits the infection of a host cell by an alphavirus.
An article of manufacture, comprising at least one alphavirus capsid protein or a portion thereof.
Dependencies are inferred from the claim text.