A Ribozyme Comprising a Target-Binding Domain

A ribozyme comprising:

• a) one or more catalytic domains capable of switching between an active state and an inactive state;
• b) one or more releasable RNA segments, wherein each of said releasable RNA segment is flanked by two ribozyme cleavage sites, wherein each cleavage site is cleaved by at least one of the one or more catalytic domains in an active state;
• c) one or more target-binding domains, each of which is for the binding of a target RNA molecule;
• wherein each of the one or more catalytic domains is linked to one of the one or more target-binding domains;
• wherein the catalytic domain is in an inactive state when the target-binding domain linked to said catalytic domain is not bound by the target RNA molecule, and wherein the catalytic domain is in an active state when the target-binding domain linked to said catalytic domain is bound by the target RNA molecule;
• and
• wherein when both cleavage sites flanking a releasable RNA segment are cleaved by the one or more catalytic domains, the one or more releasable RNA segment is released from the ribozyme.