Antibacterial aminoglycoside derivatives
AssigneeZhuohe Pharmaceutical Group Co., Ltd
InventorsDongdong TANG, Zhigang HUANG, Cheng LI, Charles Z. DING, Shuhui CHEN
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Abstract
Disclosed are a new class of antibacterial aminoglycoside derivatives, pharmaceutical compositions containing such compounds, and application thereof in the preparation of drugs for treating diseases related to bacterial infections. Specifically disclosed are a compound represented by formula (II), pharmaceutically acceptable salts thereof, and isomers thereof.
Claims20
A compound represented by formula (II), a pharmaceutically acceptable salt thereof, or an isomer thereof:
- wherein,
- L is —O—CH2—CH2— or —CH2—;
- R1 is H or C1-3 alkyl;
- R2 is H, C1-3 alkyl or
- wherein C1-3 alkyl is optionally substituted by 1, 2 or 3 substituent(s) independently selected from the group consisting of F, Cl, Br, I, —OH, —OCH3—CN, —NH2 and —NO2;
- Ra and Rb each independently is H, —C(═O)—NH2, —C(═O)—C1-3 alkyl or C1-3 alkyl, wherein —C(═O)—C1-3 alkyl and C1-3 alkyl are optionally substituted by 1, 2 or 3 R;
- and
- each R is independently F, Cl, Br, I, —OH, —OCH3, —CN or —NH2.
A compound of the following formula, the pharmaceutically acceptable salt thereof or the isomer thereof:
Dependencies are inferred from the claim text.