Nanofiber Structures and Methods of Use Thereof
AssigneeBoard of Regents of the University of Nebraska
InventorsJingwei Xie, Shixuan Chen, Mark Carlson
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Abstract
Coated and expanded, nanofiber structures are provided and methods of use thereof.
Claims18
A nanofibrous structure comprising:
- a) an expanded, nanofiber structure comprising a plurality of nanofibers;
- and
- b) a coating comprising a material with water absorbing properties.
The nanofibrous structure of any one of the preceding claims, wherein said nanofiber structure of a) comprises a plurality of uniaxially-aligned nanofibers, random nanofibers, and/or entangled nanofibers.
The nanofibrous structure of any one of the preceding claims, wherein said nanofiber structure of a) comprises electrospun fibers.
The nanofibrous structure of any one of the preceding claims, wherein said nanofibers comprise hydrophobic polymers.
The nanofibrous structure of any one of the preceding claims, wherein said coating comprises a hydrogel.
The nanofibrous structure of any one of the preceding claims, wherein said coating comprises a material selected from the group consisting of gelatin, chitosan, starch, pectin, cellulose, methylcellulose, sodium polyacrylate, and starch-acrylonitrile co-polymers.
The nanofibrous structure of any one of the preceding claims, wherein said coating is crosslinked.
The nanofibrous structure of any one of the preceding claims, further comprising a therapeutic agent.
A method for the inhibiting, preventing, and/or treating bleeding and/or hemorrhaging in a subject in need thereof, said method comprising administering the nanofibrous structure of any of the preceding claims to the site of bleeding.
Dependencies are inferred from the claim text.