Medical device with a biocompatible coating
OwnerPedro Lylyk, Noureddline Frid +2inventors
InventorsPedro Lylyk, Noureddline Frid, Laurence Gebhart, Nils Köntges
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Abstract
An implantable medical device comprising (a) a metallic substrate and (b) a bisphosphonate wherein both phosphorus atoms contained in the bisphosphonate are covalently attached to a same carbon atom. The bisphosphonate continuously coats the external surface of the metallic substrate as monolayer and as outermost layer. At least one phosphonate moiety of the bisphosphonate is covalently and directly bonded to the external surface of the metallic substrate and/or covalently bonded to another molecule of the bisphosphonate in the coating.
Claims5
A vascular endoprosthesis comprising:
- (a) a metallic substrate;
- and
- (b) a bisphosphonate having the general formula (I),
- wherein
- R1 represents (i) —C1-5 unsubstituted alkyl, or (ii) Cl;
- R2 represents —H, —OH or —Cl;
- M1, M2, M3, M4 are each a hydrogen atom or a metallic atom,
- the bisphosphonate is continuously coated on an external surface of the metallic substrate as a monolayer and as an outermost layer, and
- at least one phosphonate moiety of the bisphosphonate is covalently and directly bonded to the external surface of the metallic substrate in the coating.
Dependencies are inferred from the claim text.