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US 2022/0213159 A1Published application
Novel cancer antigens and methods
AssigneesThe Francis Crick Institute Limited, Enara Bio Limited
InventorsGeorge KASSIOTIS, George YOUNG, Jan ATTIG, Fabio MARINO
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Abstract
There are disclosed inter alia polypeptides and nucleic acids encoding said polypeptides which are useful in the treatment, prevention and diagnosis of cancer, particularly melanoma, especially cutaneous melanoma and uveal melanoma.
Claims21
1-66. (Canceled)
A composition comprising an isolated polypeptide and an immunostimulant, wherein:
- (a) the isolated polypeptide comprises an amino acid sequence selected from the group consisting of SEQ ID NO:
- 1-8, or an immunogenic fragment or variant of any one thereof;
- (b) the isolated polypeptide comprises an amino acid sequence selected from the group consisting of SEQ ID NO:
- 1-8, 9-22, and 39;
- or
- (c) the amino acid sequence of the isolated polypeptide consists of an amino acid sequence selected from the group consisting of SEQ ID NO:
- 1-8, 9-22, and 39.
4 more elements
A method of diagnosing a subject as suffering from a cancer, the method comprising determining if cells of the subject comprise a polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO:
- 1-8, or an immunogenic fragment or variant of any one thereof, or a nucleic acid sequence expressing the polypeptide, wherein the presence of the polypeptide or nucleic acid sequence in the cells indicates that the subject has cancer.
Dependencies are inferred from the claim text.