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US 2022/0205914 A1Published application
Plate imager
AssigneeQ-State Biosciences, Inc.
InventorsGabriel Benito Borja, Steven Nagle, Christopher Werley, Yang Lu, Adam Barnett, Owen McManus, Graham T. Dempsey
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Abstract
The present invention includes multi-well plate readers, and methods of their use. The multi-well plate readers can transmit stimulation light to, and detect emission light from, individual wells of a multi-well plate at a plurality of distinct wavelengths.
Claims36
A multi-well plate reader comprising:
- a reading platform configured to receive a multi-well plate;
- at least one objective disposed at the platform;
- and
- an optical subsystem comprising:
- one or more light sources operable to transmit stimulation light through the objective to a well of the multi-well plate, and
- one or more optical filters or dichroic mirrors operable to pass emission light of a first wavelength from the well along a first optical path through the objective to a first light detector and emission light of a second or third wavelength from the well along a second or third optical path to a second or third light detector.
3 more elements
A multi-well plate reader comprising:
- a reading platform configured to receive a multi-well plate;
- a read head assembly comprising a plurality of objective lenses;
- and
- a plate pusher that displaces the multi-well plate with respect to the read assembly to align each of a plurality of wells of the multi-well plate with a different objective lens of the read head assembly.
1 more element
A multi-well plate reader comprising:
- a reading platform configured to receive a multi-well plate;
- a read head assembly comprising a plurality of objective lenses;
- and
- a microfluidic assembly to deliver fluids to wells in said multi-well plate;
- and
- a facility to enable simultaneous loading of a plurality of plates and automated sequential reading of each plate.
3 more elements
A method for imaging a sample, the method comprising:
- positioning a multi-well plate containing a biological sample in a well of the plate onto a reading platform of a plate reader, wherein the plate reader comprises at least one objective disposed at a well of the multi-plate;
- passing emission light of a first wavelength from the well through the objective and along a first optical path to a first light detector;
- and
- passing emission light of a second and/or third wavelength from the well through the objective and along a second and/or third optical path to a second and/or third light detector.
1 more element
Dependencies are inferred from the claim text.