Compositions and methods of treating asthma

A method comprising:

• administering to an individual a composition comprising, or a bacterial extract obtained from, Corynebacterium microorganisms and Dolosigranulum microorganisms at a dose sufficient to increase a proportion of the Corynebacterium microorganisms and Dolosigranulum microorganisms in the nasal microbiota of the individual, relative to a proportion of Moraxella, Staphylococcus, and/or Streptococcus microorganisms in the nasal microbiota of the individual, wherein the individual has asthma or early signs of loss of asthma control.

A method comprising:

• assaying a biological sample obtained from an individual for a proportion of Corynebacterium microorganisms and Dolosigranulum microorganisms, wherein the individual has asthma or early signs of loss of asthma control;
• and
• administering a therapy to the individual.

A method comprising:

• acquiring a biological sample from an upper airway of an individual with early signs of loss of asthma control;
• assaying an amount, concentration, or proportion of Corynebacterium microorganisms and Dolosigranulum microorganisms in the biological sample.