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US 2022/0196673 A1Published application
Recombinant baculoviruses and their uses in detecting arthropod-borne virus
AssigneeChung Yuan Christian University
InventorsTzong-Yuan WU, Szu-Cheng KUO, Pei-Yun SHU, Chang-Chi LIN, Der-Jiang CHIAO, Ying-Ju CHEN, Yi-Ting LIN, Shu-Fen CHANG, Chien-Ling SU
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Abstract
Disclosed herein are recombinant baculoviruses suitable for detecting the presence of arthropod-borne viruses in a biological sample of a test subject. The information derived from the detection may also be used to render a diagnosis on whether the test subject is infected with the arthropod-borne viruses or not, so that proper course of treatment may be assigned to the subject.
Claims6
A method of detecting an antibody against an arthropod-borne virus in a biological sample comprising:
- mixing the biological sample with a recombinant baculovirus having a viral protein of the arthropod-borne virus expressed thereon, wherein the arthropod-borne virus is Japanese encephalitis virus (JEV) or Zika virus (ZIKV), and the viral protein is selected from the group consisting of pre-M, E and a combination thereof;
- and
- detecting a complex formed between the antibody and the recombinant baculovirus, in an immunological assay.
Dependencies are inferred from the claim text.