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US 2022/0195072 A1Published application
Targeted anticoagulant
AssigneeNorthwestern University
InventorsGuillermo A. Ameer, Yunxiao Zhu
Life of this patent
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Abstract
Provided herein is technology relating to anticoagulant therapies and particularly, but not exclusively, to anticoagulant compositions for localized and targeted administration and related methods and kits for treatment of a subject with a localized and targeted anticoagulant therapy.
Claims16
1-51. (canceled)
A composition for reducing coagulation of blood, the composition comprising heparin covalently linked by a N-β-maleimidopropionic acid hydrazide (BMPH) linker to a fibrin-binding peptide, wherein the fibrin-binding peptide comprises the amino acid sequence CREKA (SEQ ID NO:
- 1) or a conservative variant thereof.
Dependencies are inferred from the claim text.