Overexpression of immunoproteasome in host cells for generating antigen-presenting cells
AssigneeIntellistem Technologies Inc.
InventorsRiam Shammaa, Moutih Rafei
Life of this patent
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Abstract
The present disclosure concerns genetically modified host cells that express an immunoproteasome in the absence of induction by or contact with a cytokine. The genetically modified stem cells are useful, for example, for vaccine production, and identification of new target antigens.
Claims39
A genetically modified host cell having one or more heterologous nucleic acid molecule encoding one or more polypeptide for the expression of an enzyme having immunoproteasome activity, wherein the heterologous nucleic acid molecule allows for the digestion and/or cross-presentation of antigen protein by the genetically modified host cell.
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The method of claim comprising treating a patient with the collected filtrates.
Dependencies are inferred from the claim text.