Compositions of nitrates and methods of use thereof
AssigneeHeartbeet Ltd.
InventorsJon Lundberg, Eddie Weitzberg
Life of this patent
Estimating the term…
Abstract
Inorganic anions nitrate and nitrite influence metabolic rate and glucose homeostasis. Infusion of nitrite iv caused an acute drop in resting energy expenditure (oxygen consumption) and nitrate, when given perorally, caused a reduction in oxygen consumption during exercise and a depression of the increase in blood glucose observed after an oral glucose tolerance test. The doses of nitrate and nitrite did not cause any detectable change in methemoglobin levels of blood. Also, nitrate and nitrite did not alter lactate levels in blood. This discovery provides useful treatments to regulate the energy expenditure and glucose homeostasis of a mammal by administration of inorganic nitrite and/or nitrate.
Claims30
A nutritional supplement or a nutritional food composition comprising a botanical source of inorganic nitrate and a nitrite salt, wherein the nitrate from said botanical nitrate source and the amount of said nitrite salt is in a molar ratio of about 5:1 to 100:1, wherein one dose of the composition provides said nitrite salt in an amount of about 0.070-700 mmol.
The nutritional supplement or a nutritional food composition according to 1, wherein said composition is in the form of, or constitutes a part of, a food product.
A supplement or nutritional food composition comprising inorganic nitrate and inorganic nitrite in a molar ratio of about 5:1 to 100:1, and a nitrite-reduction enhancing compound, wherein said inorganic nitrate is provided as a botanical source of nitrate, said inorganic nitrite is provided as a salt, and one dose of the composition provides said inorganic nitrite is an amount of about 0.070-700 mmol.
A supplement or nutritional food composition comprising inorganic nitrate and inorganic nitrite in a molar ratio of about 5:1 to 100:1 nitrate to nitrite, a nitrite-reduction enhancing compound, and a source of polyphenols, wherein said inorganic nitrate is provided as a botanical source of nitrate, and said inorganic nitrite is provided as a salt and one dose of the composition provides said inorganic nitrite in an amount of about 0.070-700 mmol.
Dependencies are inferred from the claim text.