Trait prediction model generation apparatus, trait prediction apparatus, and method for generating a trait prediction model
AssigneeKabushiki Kaisha Toshiba
InventorsMasahiro OZAWA, Chenyuan XU, Kosuke HARUKI
Life of this patent
Estimating the term…
Abstract
According to one embodiment, a trait prediction model generation apparatus generates a plurality of first trait prediction models for each of a plurality of populations, based on summary statistics and inter-polymorphism correlated information. The apparatus generates a second trait prediction model for a specific one of the populations based on regularized regression of the first trait prediction models of each of the populations using a plurality of data sets including single-nucleotide polymorphism data and a trait value.
Claims11
A trait prediction model generation apparatus comprising a processing circuit configured to:
- generate a plurality of first trait prediction models for each of a plurality of populations, based on summary statistics and inter-polymorphism correlated information;
- and
- generate a second trait prediction model for a specific one of the populations based on regularized regression of the first trait prediction models of each of the populations using a plurality of data sets including single-nucleotide polymorphism data and a trait value.
A trait prediction apparatus comprises a processing circuit configured to:
- acquire single-nucleotide polymorphism data on one individual;
- apply the single-nucleotide polymorphism data to each of a plurality of trait prediction models to calculate a plurality of first trait values for the one individual;
- calculate a second trait value for the individual based on the first trait values and a plurality of weighted average parameters which correspond to the trait prediction models, respectively and which are associated with a population to which the individual belongs;
- and
- output the second trait value.
A method for generating a trait prediction model, comprising:
- generating a plurality of first trait prediction models for each of a plurality of populations, based on summary statistics and inter-polymorphism correlated information;
- and
- generating a second trait prediction model for a specific one of the populations, based on regularized regression of the first trait prediction models of each of the populations using a plurality of data sets including single-nucleotide polymorphism data and a trait value.
Dependencies are inferred from the claim text.