Enhanced testing and characterization techniques for phototherapeutic light treatments

Abstract

Devices and methods for impinging light on tissue to induce one or more biological effects, and more particularly enhanced testing and characterization techniques for phototherapeutic light treatments are disclosed. Such testing and characterization techniques may be particularly useful in the evaluation and development of light-based treatments for various infectious diseases, including multiple variants of SARS-CoV-2. In particular aspects, testing and characterization techniques are related to the direct testing of differentiated tissue models of human airway epithelia that have been exposed to various pathogens. Phototherapeutic light treatments and corresponding treatment protocols for light are also described that not only inactivate SARS-COV-2 variants in cell-free suspensions, but also inhibit SARS-CoV-2 infections at multiple stages of infection in tissue models of human airway epithelia in a variant-agnostic manner.

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