Detection of annotated regions of interest in images

A method of identifying regions of interest (ROIs) in images, comprising:

• identifying, by a computing system, an image including an annotation defining an ROI, the image having a plurality of pixels in a first color space;
• converting, by the computing system, the plurality of pixels from the first color space to a second color space to differentiate the annotation from the ROI;
• selecting, by the computing system, from the plurality of pixels, a first subset of pixels corresponding to the annotation based at least on a color value of at least one of the first subset of pixels in the second color space;
• identifying, by the computing system, a second subset of pixels included in the ROI from the image using the first subset of pixels;
• and
• storing, by the computing system, in one or more data structures, an association between the second subset of pixels and the ROI defined by the annotation in the image.