Compositions and methods for detection of disease-related antibody
AssigneesUniversity of Pittsburgh—Of the Commonwealth System of Higher Education, Upmc
InventorsSarah E. WHEELER, Michael R. SHURIN, Li LIU
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Abstract
Disclosed herein are compositions and uses thereof for detection of disease-related antibodies. The methods include contacting a biological sample with a solid support comprising one or more antigens that bind one or more therapeutic monoclonal antibodies, and detecting the disease-related antibody in the biological sample using an electrophoretic method.
Claims25
A method of detecting a disease-related antibody in a biological sample containing one or more therapeutic monoclonal antibodies comprising:
- a. contacting the biological sample with a solid support having one or more antigens bound thereto, wherein the one or more antigens are specific for the one or more therapeutic monoclonal antibodies, and
- b. detecting the disease-related antibody in the biological sample using an electrophoretic method.
A kit for removing one or more therapeutic monoclonal antibodies from a biological sample, said kit comprising a solid support and one or more antigens, wherein the one or more antigens are specific for the one or more therapeutic antibodies.
Dependencies are inferred from the claim text.