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AssigneeChugai Seiyaku Kabushiki Kaisha
InventorsTomoyuki IGAWA, Shinya ISHII, Miho FUNAKI, Naoka HIRONIWA, Shun SHIMIZU
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Disclosed is a library consisting essentially of a plurality of antigen-binding molecules differing in sequence from each other, wherein an antigen-binding domain in each of the antigen-binding molecules comprises at least one amino acid residue that changes the antigen-binding activity of the antigen-binding molecule depending on ion concentration conditions. Also disclosed are a composition comprising a plurality of polynucleotide molecules each encoding the antigen-binding molecules, a composition comprising a plurality of vectors each comprising the polynucleotide molecules, a method for selecting the antigen-binding molecules, a method for isolating the polynucleotide molecules, a method for producing the antigen-binding molecules, and a pharmaceutical composition comprising any of the antigen-binding molecules.
-82. (canceled)
A library for screening an antigen-binding molecule, which binds to an antigen of interest, consisting of a plurality of antigen-binding molecules differing in sequence from each other, wherein an antigen-binding domain in each of the antigen-binding molecules is a heavy chain variable region and a light chain variable region of an antibody, and
A method for preparing a library for screening an antigen-binding molecule, which binds to an antigen of interest,
(canceled)
Dependencies are inferred from the claim text.