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US 2022/0187307 A1Published application
Biomarkers for improving nutrion for infants at risk
AssigneeN.V. Nutricia
InventorsHugo Philemon van Bever, Elena Sandalova, Alma Jildou Nauta
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Abstract
The invention relates to biomarkers in the umbilical cord epithelium relating to skin proteins that are better predictive for the development of atopic dermatitis late in life. These biomarkers enable an early nutritional intervention in a more precisely determined population of at risk infants.
Claims22
A method for determining the risk of an infant to develop an atopic disease, wherein the method comprises:
- a) determining in vitro the level of at least one biomarker protein from umbilical cord epithelial cells in a sample comprising umbilical cord epithelial cells from the infant, and
- b) comparing the level of the at least one biomarker protein to a reference value, and wherein an increase in the level of the at least one biomarker protein in the sample compared to the reference value indicates an increased likelihood to develop the atopic disease, wherein the reference value is based on an average level of the same at least one biomarker protein in a healthy reference group of infants that did not develop an atopic disease at the age of three months.
A method for customizing a diet for an infant at risk of developing an atopic disease, comprising
- a) determining in vitro the level of at least one biomarker protein from umbilical cord epithelial cells in a sample comprising umbilical cord epithelial cells from the infant, and
- b) comparing the level of the at least one biomarker protein to a reference value, and in case of an increase in the level of the at least one biomarker protein in the sample compared to the reference value providing an atopic disease customized diet for the infant, wherein the reference value is based on an average level of the same at least one biomarker protein in a control group that did not develop an atopic disease at the age of three months.
(canceled)
A method for preventing atopic disease in an infant, the method comprising:
- a) determining in vitro the level of at least one biomarker protein from umbilical cord epithelial cells selected from the group consisting of loricrin, GATA-3, and kallikrein-7, in a sample comprising umbilical cord epithelial cells from the infant, and
- b) comparing the level of the at least one biomarker protein to a reference value and in case of an increase in the level of the at least one biomarker protein in the sample compared to the reference value;
- administering a nutritional composition comprising at least one selected from the group consisting of hydrolysed protein, lactic acid producing bacteria and non-digestible oligosaccharides to the infant,
- wherein the reference value is based on an average level of the same at least one biomarker protein in a control group that did not develop an atopic disease at the age of three months.
1 more element
Dependencies are inferred from the claim text.