Thread spray ambient ionization
AssigneeOhio State Innovation Foundation
InventorsAbraham BADU-TAWIAH, Devin SWINER, Sierra JACKSON
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Abstract
Disclosed herein are methods and apparatus useful for the collection, preservation, and analysis of biological fluids. In some embodiments, a hydrophobic thread is contacted with a biological sample. The hydrophobic thread stabilizes the biological sample over prolonged periods of time. Compounds, including small molecules and/or biopolymers, can be ionized by applying a suitable voltage to the tread. These ionized compounds can then be analyzed, for instance using mass spectrometry.
Claims24
A method for ionizing a compound, comprising:
- (a) contacting a thread with a sample comprising the compound;
- (b) disposing the thread in a non-conductive chamber;
- and
- (c) applying a direct current voltage to the thread.
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A swab for microsampling, comprising a rod, a thread coupled to the rod, said thread coiled around at least of portion of the rod, and wherein the rod is axially slideable relative to the central axis of the coil.
An immunoassay kit, comprising:
- a thread conjugated to a capture antibody;
- and
- a composition comprising a reporter antibody.
Dependencies are inferred from the claim text.